天津医科大学第二医院Disease Markers被质疑

标题：The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer

期刊：Disease Markers

单位：天津医科大学第二医院&天津医科大学总医院

发表时间：2019年3月3日

DOI: 10.1155/2019/5380197

研究摘要：

Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical and biological significance of PTK7 in cervical cancer is still unknown. In the present study, the protein expression level of PTK7 was detected in clinical cervical cancer patient samples, and the relationship between PTK7 expression and clinicopathological features was analyzed. In addition, the Kaplan-Meier method was performed to estimate the overall survival (OS) and progression-free survival (PFS) of patients to investigate the clinicopathological significance of PTK7 expression. Functional assays demonstrated that knocking down PTK7 might inhibit the ability of cancer cells to proliferate and invade or migrate, both in vivo and in vitro. Thus, PTK7 might serve as a potential target for cervical cancer.
子宫颈癌是妇科最常见的恶性肿瘤之一。蛋白酪氨酸激酶 7（PTK7）具有非活性激酶结构域，是正常和多种病理条件下多个 Wnt 通路的重要调节因子，在各种肿瘤中过表达；然而，PTK7 在子宫颈癌中的临床和生物学意义尚不清楚。在本研究中，检测了临床子宫颈癌患者样本中 PTK7 蛋白的表达水平，并分析了 PTK7 表达与临床病理特征之间的关系。此外，采用 Kaplan-Meier 方法估计患者的总生存期（OS）和无进展生存期（PFS），以研究 PTK7 表达的病理临床意义。功能实验表明，敲低 PTK7 可能抑制癌细胞在体内和体外增殖、侵袭或迁移的能力。因此，PTK7 可能成为子宫颈癌的潜在治疗靶点。

具体说明

参考信息
https://pubmed.ncbi.nlm.nih.gov/30944666/

https://pubpeer.com/publications/CCB162A11B29CCE91F815B29EBB88F#0

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