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2025年4月，国家自然科学基金委员会监督委员会对江苏省人民医院徐泽宽等发表的论文涉嫌学术不端开展了调查。涉及的论文如下：

论文信息一

Zekuan Xu*, et al. miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer. Cell Proliferation, 2019, 52(3): e12567.（标注基金号81572362、81361120398）

质疑信息

#1 Clockwise from upper left:

Fig 2d from "Targeting the miR-6734-3p/ZEB2 axis hampers development of non-small cell lung cancer (NSCLC) and increases susceptibility of cancer cells to cisplatin treatment" (Wei & Jiang et al 2021)..

Fig 1H,I (colony plates).

Fig 2c from "Investigations on the Role of the MicroRNA-338-5p/Wnt Family Member 2B (WNT2B) Axis in Regulating the Pathogenesis of Nasopharyngeal Carcinoma (NPC)" (Wang et al 2021).

#2 [left] Fig 8a from "Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression" (Huang et al 2019).

[right] Fig 5A.

#3 Figs 2C,D and 4G,H. Many overlaps.

该论文2024年5月28日被撤稿：

https://onlinelibrary.wiley.com/doi/10.1111/cpr.13681

上述文章于2019年3月18日在Wiley在线图书馆（wileyonlinelibrary.com）在线发表，现已由期刊主编周琦与John Wiley and Sons有限公司协商一致后撤回。文章发表后，第三方对图2c、2d、4g、4h和5a存在疑似重复的问题提出了质疑。作者解释称，这些重复是由于数据存储过程中的疏忽造成的。鉴于所犯错误的程度和性质，编辑们对本研究的结果和结论已失去信心。

论文信息二

Zekuan Xu*, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Molecular Cancer, 2019, 18(1): 20.（标注基金号81572362、81361120398）

质疑信息

#1 [left] Fig 5E.

[right] Fig 2E from "Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis" (Yang et al 2021).

[left] Fig 2F from "Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis" (Zhang et al 2018).

[right] Fig 5E again.

#2 Figs 5B and 6B. Some panels have accidentally been reused.

论文信息三

Zekuan Xu*, et al. Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. Cell Death and Disease, 2021, 12(10): 910.（标注基金号81871946、82072708）

质疑信息

#1 [left] Fig 5B.

[right] Fig 7B from "The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis" (Xu et al 2022).

#2 Figs 2C and 5C. A column of panels is duplicated.

#3 [left] Fig 5E from "Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway" (Zhang et al 2019).

[right] Fig 2E.

论文信息四

Zekuan Xu*, et al. Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis. Journal of Experimental & Clinical Cancer, 2018, 37(1): 320.（标注基金号81572362、81361120398）

质疑信息

#1 Overlap was detected in Fig. 5D.

#2 [left] Fig 2F.

[right] Fig 5E from "Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway" (Zhang et al 2019).

#3 Fig 2E. An unfortunate confusion has occurred.

Figs 7D, 2E. Another confusion.

#4 Figs 2D, 5A.

#5 Figs 2C, 7C.

#6 Fig 10F.

该论文2024年7月18日被撤稿：

https://jeccr.biomedcentral.com/articles/10.1186/s13046-024-03123-7

主编已撤回本文。文章发表后，有人对部分图表中呈现的数据提出了质疑，具体如下：

图2C中BGC-823 miR-NC图像与图7C中MKN45 LV-miR-IN＋si GLS图像似乎重叠。

图2D中BGC-823 NC图像与图5A中MKN-45 miR-133a-3p IN+、HCQ+图像高度相似。

图2E中MKN-45侵袭miR-133a-3p模拟图像与BGC-823侵袭miR-133a-3p模拟图像似乎重叠。

图2E中BGC-823迁移miR-133a-3p模拟图像与图7D中BGC-823迁移LV-miR-IN＋BPTES图像似乎重叠。

图2F中miR-133a-3p模拟第10天图像与文献[1]中图5E中circNRIP1过表达第1天图像高度相似。

图5D中侵袭miR-IN＋si GABARAPL1和miR-IN＋HCQ图像似乎重叠。

图10F中GLS LV-miR-133a-3p图像与GDH LV-miR＋HCQ＋BPTES图像似乎重叠。

因此，主编对所呈现的数据不再有信心。

Xing Zhang, Zheng Li, Zhe Xuan, Penghui Xu和Zekuan Xu同意此次撤稿。Weizhi Wang, Zheng Chen, Sen Wang, Guangli Sun和Jianghao Xu未就此次撤稿事宜回复编辑或出版方的任何函件。

涉及文章

[1] Zhang X, Wang S, Wang H, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 2019;18:20. https://doi.org/10.1186/s12943-018-0935-5

论文信息五

Zekuan Xu*, et al. ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway. Tumor Biology, 2016, 37(9): 12813-12821.（标注基金号81272712、81572362、812111519）

质疑信息

#1 In Figure 3a, two dependent experiments used the same picture

#2 In Figure 2f, The wound healing assay of ZNF143 knock down was similar to Scr

#3 The data was also observed in the Master Dissertation of Song Wei !

 

论文信息六

Zekuan Xu*, et al. miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10. Molecular Therapy: Nucleic Acids, 2017, 9: 294-311.（标注基金号81361120398、81572362）

质疑信息

#1 Figure 9I appears to have two images which overlap. This seems to be a systematic issue in papers with at least one common author: https://pubpeer.com/search?q=authors%3A"Zekuan+Xu"

https://www.sciencedirect.com/science/article/pii/S2162253122001226

在收到其中一位作者的电子邮件后，我们发现了图7J、图9C和补充图S2中存在以相同或修改方式重复使用图像的证据。这种未经适当署名而重复使用（以及部分歪曲）数据的行为，严重滥用了科学出版体系。作者们同意撤稿。

论文信息七

Zekuan Xu*, et al. Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer. Journal of Experimental & Clinical Cancer Research, 2017, 36(1): 59.（标注基金号81361120398、81572362）

质疑信息

#1 Two images in Figure 7a appear to overlap, although the aspect ratio differs significantly, suggesting that this was not merely an error during figure assembly.

论文信息八

Zekuan Xu*, et al. Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway. Oncotarget, 2017, 8(31): 51177-51189. （标注基金号81572362、81602080、812111519）

质疑信息

#1 Figure 2F appears to have two sets of images which overlap. This type of issue is sometimes seen in papers that have been "outsourced."  

#2 Figures 3F and 3H, 4E and 4I also seem to have overlaps. TAM.

论文信息九

Zekuan Xu*, et al. MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer. Cell Death & Disease, 2018, 9(5): 505.（标注基金号81572362、81361120398）

质疑信息

#1 Figure 7B appears to have at least two sets of bands that have been repurposed.

论文信息十

Zekuan Xu*, et al. miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. Oncotarget, 2015, 6(3): 1605-17.（标注基金号81361120398、81272712、30901421）

调查内容

经查，10篇涉事论文多幅图片相同但代表不同含义，存在图片虚假的客观结果。10篇论文的通讯作者徐泽宽等人应对论文存在的问题负责。

此外，徐泽宽将论文1至论文3、论文5至论文8、论文10分别列入相关基金项目（批准号81572362、81871946、81361120398）申请书或进展报告、结题报告。徐泽宽还应对此问题负责。

经国家自然科学基金委员会监督委员会六届五次会议审议，由国家自然科学基金委员会2024年第20次委务会议审定，决定依据《国家自然科学基金项目科研不端行为调查处理办法》第四十七条、第四十条、第四十六条，撤销徐泽宽国家自然科学基金项目“幽门螺旋杆菌通过促进BRD2m6A修饰打破FLIP/Caspase-8稳态增强胃癌细胞化疗敏感性的机制研究”（批准号82072708）、“胃癌细胞来源外泌体miR-519a-3p通过抑制肝Kupffer细胞Lefty1分泌以促进肝转移灶形成的机制研究”（批准号81871946）、“慢性应激在胃癌发生过程中的作用及机制研究”（批准号81572362）、“MUC4独有结构域NIDO、AMOP及vWD在胰腺癌特征性肿瘤学行为中的作用及机制研究”（批准号81272712）和“异常表达微小RNA对胃癌发生发展过程的调控研究”（批准号81361120398），追回上述5个项目的已拨资金，取消徐泽宽国家自然科学基金项目申请和参与申请资格3年（2024年12月10日至2027年12月9日），给予徐泽宽通报批评。

参考信息：

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