第一作者：吉林大学第一医院 Jianfeng Mu

通讯作者：吉林大学第二医院 Pengda Sun （音译 孙鹏达）

#1 [left] Fig 4c. "Representative IHC staining of BRD4 and CD31 in the two groups".

Two panels are (rotated) enlargements of [right] Fig 4 from "Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry" (Kluk et al 2013): "NICD1 immunoreactivity in archival FPE human cancers".

DataTwin图片查重

#2 [left] Fig 7A. The panels are sourced from [right] Figs 3 and 4 of "Immunohistochemistry of Colorectal Cancer Biomarker Phosphorylation Requires Controlled Tissue Fixation" (Theiss et al 2014).

#3 [above] Fig 3E/F.

[below] Fig 3A from "Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation" (Sato et al 2016).

#4 [left] Fig 1C. Two panels are rotated details of Fig 6 from "FGFR2 Is Amplified in the NCI-H716 Colorectal Cancer Cell Line and Is Required for Growth and Survival" (Mathur et al 2014).

#5 Figs 2E,F.

Rotated through 90 deg, to highlight the panels' origins as details of panels from Figs 2E, 4F of "LncRNA TTN?AS1 promotes endometrial cancer by sponging miR?376a?3p" (Shen et al 2020).

Also the MKN-45 panels of Fig 3B from "MicroRNA?9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin?1" (Hang et al 2019).

撤稿原因

本文已于2025年3月17日被撤回：

主编们已撤回本文，原因是本文所呈现的图片存在问题，这些问题对文章的整体科学严谨性提出了质疑。文章发表后进行的调查发现存在以下问题：

图1C中的正常组、病例1组和病例1肿瘤组图片在旋转后与文献[1]中图6的H716组和CO802 D5组图片似乎存在重叠；

图2E中的Vector, GIST-T1组图片在旋转后与文献[2]中图3B的mir-9-5p mimics control, MKN-45组图片似乎存在重叠；

图2E中的Vector, GIST-882组图片在旋转后与文献[3]中图4E的HEC1A, si-TTB-AS1+miR-NC组图片似乎存在重叠；

图3E中的BRD4组图片在旋转后与文献[4]中图3A的第一组图片似乎存在重叠；

图4C中的Vector, BRD4和BRD4, BRD4组图片在旋转后与文献[5]中图4的C和E组图片似乎存在重叠；

图7A中的四个面板图片在旋转后与文献[5]中图3的24h, BRAF V600E, 24h, pEGFR, 24h, EGFR组图片以及图4的Ischemia, BRAF V600E组图片似乎存在重叠；

图3F中的两个面板图片在旋转后与文献[6]中图3A的第二和第三组图片似乎存在重叠。

上述存在问题的图片代表了在不同实验条件下取自动物的组织。因此，主编们不再相信本文所呈现研究的完整性。

作者未回复出版商关于此次撤回的信件。

涉及文章

[1] Mathur A, Ware C, Davis L, Gazdar A, Pan B-S, Lutterbach B. FGFR2 is 

amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS ONE. 2014;9:e98515.

[2] Hang C, Yan H, Gong C, Gao H, Mao Q, Zhu J. MicroRNA-9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin-1 Retraction in /10.3892/etm.2024.12687. Exp Ther Med. 2019;18:2524–2530.

[3] Shen L, Wu Y, Li A, Li L, Shen L, Jiang Q, et al. [Retracted] LncRNA TTN-AS1 promotes endometrial cancer by sponging miR-376a-3p. Oncol Rep. 2024;52:161. 

[4] Theiss AP, Chafin D, Bauer DR, Grogan TM, Baird GS. Immunohistochemistry of colorectal cancer biomarker phosphorylation requires controlled tissue fixation. PLoS ONE. 2014;9:e113608.

[5] Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, et al. Gauging NOTCH1 activation in cancer using immunohistochemistry. PLoS ONE. 2013;8:e67306. 

[6] Sato A, Kamekura R, Kawata K, Kawada M, Jitsukawa S, Yamashita K, et al. Novel mechanisms of compromised lymphatic endothelial cell homeostasis in obesity: the role of leptin in lymphatic endothelial cell tube formation and proliferation. PLoS ONE. 2016;11:e0158408.

参考信息
https://pubpeer.com/publications/B07B4AFC1C6F49E6C37EF6210242CC#2

https://pubmed.ncbi.nlm.nih.gov/31322233/

https://www.spandidos-publications.com/10.3892/mmr.2025.13493