四川农业大学理学院张利团队的论文惊现大规模图像重复，Cell Proliferation研究遭严重质疑！

日期：2019年12月9日

单位与作者：四川农业大学理学院 Jin  Zhou、Li Zhang(通讯作者 音译 张利)

• Fig 2A from "Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-κB P65" (Lei et al 2020).

• Fig 3H,I from "The Down-Regulation of TrkB Alleviates the Malignant Biological Behavior and Cancer Stem-Like Property of Laryngeal Cancer" (Hu et al 2020).

• Fig 2A from "Puerarin 6″-O-xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/ mTOR" (Li et al 2020).

• Fig 1C from "Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway" (Zhou et al 2020).

• Fig 4B from "Ligustrazine inhibits the viability and motility of colon cancer cells" (Chen et al 2020).

• Fig 1B from "The anti-tumor effect of taxifolin on lung cancer via suppressing stemness and epithelial-mesenchymal transition in vitro and oncogenesis in nude mice" (Wang et al 2020).

#2 图3B与3篇论文存在严重图片重复。  

Clockwise from upper left:

• Fig 4C,D from "Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway" (Sun et al 2020).
• Fig 4C,D from "Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway" (Wei et al 2020).
• Fig 3B.
• Figs 3C, 4i from "Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo" (Ji et al 2021).

#3 图5D与2篇论文存在严重图片重复 

Fig5D

Fig 5C-F from "Tanshinone IIA suppresses ovarian cancer growth through inhibiting malignant properties and angiogenesis" (Zhou et al 2020.)

Fig 5C,D,E from "Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer" (Zhou et al 2020).

Clockwise from upper left:

• Fig 2C.

• Fig 2E,F from "Matrine inhibits ovarian cancer cell viability and promotes apoptosis by regulating the ERK/JNK signaling pathway via p38MAPK" (Liang & Ju 2021).

• Fig 2C from "Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer" (Zhou et al 2020).

Clockwise from upper left:

• Fig 3F from "The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy" (Hu et al 2020).
• Fig 3C from "Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT" (Zhang et al 2020).
• Fig 4A from "Puerarin 6″-O-xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/ mTOR" (Li et al 2020).
• Fig 4F from "MicroRNA-153-3p sensitizes melanoma cells to dacarbazine by suppressing ATG5-mediated autophagy and apoptosis" (Hou et al 2020).

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